The Nonstructural Proteins of Flaviviruses Are Produced on the Rough

question 22

Multiple Choice

The nonstructural proteins of flaviviruses are produced on the rough ER and have membrane spanning domains.Which of the following explains why the nonstructural proteins are localized to cellular membranes?

• A) Fatty acids are a required cofactor for RNA synthesis.
• B) Viral RNA replication can only occur in the lumen of the ER.
• C) Membranes serve to localize the viral replication complex.
• D) The viral replication proteins must be glycosylated before they are active.
• E) The nonstructural proteins require proteolytic processing by lysosomal enzymes.

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