In a Lysosomal Storage Disease,newly Synthesized Lysosome Hydrolases Are Secreted

question 25

Multiple Choice

In a lysosomal storage disease,newly synthesized lysosome hydrolases are secreted from the cells rather than being delivered to the lysosomes.What is one possible mechanism for this result?

• A)The cis-Golgi network lacks a proton gradient.
• B)The ER is unable to produce lysosomal vesicles.
• C)Lysosomal enzymes are not phosphorylated in the rER.
• D)Mannose is not phosphorylated in the cis-Golgi network.
• E)All the hydrolase genes are mutated,resulting in synthesis by ribosomes free in the cytoplasm rather than on the endoplasmic reticulum membrane.

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