In a Lysosomal Storage Disease,newly Synthesized Lysosome Hydrolases Are Secreted

question 25

Multiple Choice

In a lysosomal storage disease,newly synthesized lysosome hydrolases are secreted from the cells rather than being delivered to the lysosomes.What is one possible mechanism for this result?

• A)The cis-Golgi network lacks a proton gradient.
• B)The ER is unable to produce lysosomal vesicles.
• C)Lysosomal enzymes are not phosphorylated in the rER.
• D)Mannose is not phosphorylated in the cis-Golgi network.
• E)All the hydrolase genes are mutated,resulting in synthesis by ribosomes free in the cytoplasm rather than on the endoplasmic reticulum membrane.

Recognize the significance of various picketing practices and their legal status.

Understand the concept of bargaining impasse and its consequences.

Differentiate between various dispute resolution mechanisms like arbitration, fact-finding, and med-arb.

Recognize the legal and practical aspects of strike actions.

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Definitions:

Retroactive Interference

A phenomenon where new memories impair the retrieval of older memories.

Hindsight Bias

The tendency to believe, after an event has occurred, that one would have predicted or expected the outcome, often referred to as the "I-knew-it-all-along" phenomenon.

Proactive Interference

The phenomenon where previously learned information interferes with the recall of newer information.

Retroactive Interference

A cognitive phenomenon where newly learned information interferes with the recall of previously learned information.