In a GWAS Experiment, 500,000 SNPs Across the Genome Are

question 3

Multiple Choice

In a GWAS experiment, 500,000 SNPs across the genome are genotyped in thousands of Case and Control individuals.Which statistical analysis should be applied and why?

• A)A chi-square test for goodness of fit will test the null hypothesis that the distribution of each SNP allele is the same in Cases and Controls.
• B)A chi-square test for goodness of fit can be used because this is a small number of SNPs.
• C)A chi-square test for independence should be used to test the null hypothesis that the distribution of each SNP allele is the same in Cases and Controls.
• D)A chi-square test for independence should be used to test the null hypothesis that each SNP is linked to a QTL.

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