A Man Inherited a Chromosome with a Deletion That Removes

question 21

Multiple Choice

A man inherited a chromosome with a deletion that removes a tumor-suppressor gene.The protein encoded by this gene normally functions in DNA damage repair.Which series of events would be most likely to lead to cancer?

• A)Loss-of-heterozygosity of the tumor-suppressor gene followed by driver mutations in two different proto-oncogenes
• B)A loss-of-function mutation in a proto-oncogene followed by a gain-of function mutation in a tumor-suppressor gene
• C)Loss-of-heterozygosity of the tumor-suppressor gene followed by passenger mutations in several genes of unknown function
• D)A gain-of-function mutation in a proto-oncogene followed by a chromosomal duplication of a region including a tumor-suppressor gene that functions the G₁-to-S checkpoint

---

Definitions:

Subsidiary Loss

Financial losses incurred by a subsidiary, which may impact the financial position and results of the parent company.

Deferred Tax Liability

A tax obligation due in the future for income that has been recognized in the financial statements before it is taxable.

Inventory

The raw materials, work-in-process products, and finished goods that are considered to be the portion of a business's assets that are ready or will be ready for sale.

Accounts Payable

Liabilities of a business representing amounts owed to creditors for goods and services received but not yet paid for.