Fragile X Syndrome Is a Human Disease Caused by a Trinucleotide

question 12

Multiple Choice

Fragile X syndrome is a human disease caused by a trinucleotide repeat expansion that results in loss-of-function of the FMR1 gene on the X chromosome.An animal model with most features of this syndrome could be created by

• A)adding a transgene containing a mutant copy of the FMR1 gene to a mouse or primate genome.
• B)adding a transgene containing a wild-type copy of the FMR1 gene to a mouse or primate genome.
• C)knocking out both copies of the FMR1 gene from a mouse or primate genome.
• D)knocking out one copy of the FMR1 gene from a mouse or primate genome.

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Definitions:

Isthmian Canal

Refers to the Panama Canal, a man-made waterway connecting the Atlantic and Pacific Oceans through the Isthmus of Panama, completed in 1914.

France

A country in Western Europe known for its rich history, culture, and contributions to art, philosophy, and science.

Bunau-Varilla

Philippe Bunau-Varilla was a French engineer and soldier who played a significant role in the construction of the Panama Canal and its transfer to the United States.

Panamanians

People originating from or residing in Panama, a country located in the southern part of Central America.