This Pedigree Shows the Inheritance Pattern of a Disease Caused

question 5

Multiple Choice

This pedigree shows the inheritance pattern of a disease caused by a paternally imprinted allele in a family.Genetic testing of individuals I-1 and II-5 indicates they are carriers of the disease allele.No one else in the family agreed to be tested.If first cousins III-4 and III-5 have a child together (IV-1) what is the chance the child will have the disease? (assume complete penetrance) Reference for pedigree: Modified from www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(14) 00138-5

• A)0
• B)1/9
• C)1/4
• D)1/2
• E)1/3

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