Herceptin Is a Drug That Is Given to Treat Certain

question 33

Multiple Choice

Herceptin is a drug that is given to treat certain breast cancers.However, it is most effective on tumors that are overexpressing the gene HER2.Which of the following strategies would be best for determining whether Herceptin would be effective in a given patient?

• A)Sequence DNA from the patient's sperm or eggs to determine whether the patient's germ cells contain gain-of-function mutations in HER2, and treat with Herceptin only if they do.
• B)Determine the patient's HER2 sequence and compare it to a database of known HER2 mutations to determine whether the overexpression allele is present; if the overexpression allele is present, give Herceptin .
• C)Determine the patient's HER2 sequence and compare it to a database of known HER2 mutations to confirm that the patient has a mutation in the gene; give Herceptin if any mutation is found.
• D)Perform microarray analysis to determine the location of the patient's HER2 gene and give Herceptin if the HER2 gene is not in the normal location.

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Definitions:

Sample Proportion

The fraction or percentage of the sample that represents a particular trait or characteristic of interest.

Null Hypothesis

A hypothesis that assumes no significant difference or effect exists between specified populations or variables.

Population Proportion

The fraction or percentage of a population that shares a particular characteristic or attribute.

Sample Proportion

The proportion or percentage of the sample that has a particular characteristic, often used to estimate the true population proportion.