How Can Databases of Variants Be Used to Help Pinpoint

question 10

Multiple Choice

How can databases of variants be used to help pinpoint a disease-causing mutation? (Select all that apply. )

• A)Polymorphisms found in individuals that do not have the syndrome can be eliminated from consideration.
• B)Common polymorphisms are unlikely to cause a rare disease and they can be eliminated from consideration.
• C)Some amino acids are conserved in genes across species; mutations in conserved amino acids are not likely to cause disease.
• D)Mutations that occur between genes are most likely to cause a genetic disease.

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Definitions:

Increasing Acidity

A term referring to the rising strength of acid, usually measured by a decrease in pH value or an increase in the ability to donate protons (\(H^+\)) in solution.

Cycloheptatriene

A cyclic hydrocarbon with seven carbon atoms and three double bonds, known for its interesting reactivity due to aromatic destabilization.

Deprotonated

Refers to a molecule or ion that has lost a hydrogen ion (H+), resulting in a base form.

Resonance Forms

Different structures of a molecule that depict the delocalization of electrons within the molecule, explaining its stability.