Solved

Scenario Endotoxins Are Commonly Found in the Air, Both Inside and and Outside

question 44

Multiple Choice

Scenario
Endotoxins are commonly found in the air, both inside and outside our homes. These "air endotoxins" can come from sources that include house dust mites, agricultural and industrial dust, and dust from indoor pets. Air endotoxins are typically found in low amounts, but production of them can increase dramatically under specific environmental conditions such as dampness, mold, and sewage. Many scientific studies have been conducted investigating possible links between indoor endotoxin levels and asthma, chronic bronchitis, and other upper respiratory diseases. Interestingly, some studies have found positive correlations between indoor endotoxin exposure and severity of some of these diseases while other studies have suggested that some air endotoxin exposure can actually decrease the risk of developing asthma in children. Additionally, data suggest that industrial workers who are exposed to endotoxins in the air can develop irreversible lung damage.

In 2005, Hurricane Katrina devastated the eastern coastline of the United States. The state of Louisiana, and in particular the city of New Orleans, experienced tragic loss of human life and homes due to the failure of the levee system. Intense flooding destroyed homes and created severe exposure to wet, moldy surfaces. At that time there were no regulations in existence on the amount of exposure that individuals should have to air endotoxins. Scientists from the Natural Resources Defense Council who wanted to determine if endotoxin levels had risen in New Orleans conducted tests across 12 outdoor areas, 9 of which had been significantly flooded while the other 3 were less affected. Two indoor areas were also sampled for endotoxin levels. No significant differences were found in endotoxin levels between the flooded and non-flooded areas or between the indoor and outdoor areas. However, a limited number of samples were collected, and they were taken after a recent dry spell. Endotoxin levels at all sites were found to be higher than national average levels but were lower than levels typically associated with long-term changes in lung function.
-What addition to methodology would be most beneficial to the study?

Definitions:

Telophase

A phase of cell division in which chromosomes arrive at opposite poles of the cell and begin to de-condense, leading to the reformation of nuclear envelopes.

Anaphase

A phase of mitosis and meiosis during which the chromosomes separate and move to opposite ends of the cell.

Sister Chromatids

Duplicated DNA structures connected by a centromere, identical genetic information, formed during the S phase of the cell cycle.

Nuclear Envelope

A double-membrane structure that encloses the nucleus in eukaryotic cells, separating the contents of the nucleus from the cytoplasm.