Phosphofructokinase (PFK) Is an Enzyme That Converts Fructose 6-Phosphate to Fructose

question 6

Multiple Choice

Phosphofructokinase (PFK) is an enzyme that converts fructose 6-phosphate to fructose 1,6-bisphosphate, by adding a phosphate group.This is the first committed step of the metabolic pathway of glycolysis, and thus it is very tightly regulated.AMP binds to PFK at a site distinct from the binding site for fructose 6-phosphate, and stimulates the formation of fructose 1,6-bisphosphate.ATP binds to PFK at a site distinct from the binding site for fructose 6-phosphate, and inhibits the formation of fructose 1,6-bisphosphate.There are other regulators of this enzyme as well.What is the role of AMP in this example?

• A)Competitive inhibitor
• B)Noncompetitive inhibitor
• C)Allosteric inhibitor
• D)Allosteric activator

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