In the Introduction to This Chapter, the Use of the CRISPR-Cas9

question 3

Multiple Choice

In the introduction to this chapter, the use of the CRISPR-Cas9 system to make a deletion of exon 23 containing a premature stop codon in mdx mice was described. The resulting mice had partially restored dystrophin protein and muscle function. Which of the following CRISRP-Cas9 mediated changes might lead to a better restoration of dystrophin protein and muscle function?

• A) A deletion of exon 24 in addition to exon 23
• B) A deletion of intron 23
• C) A deletion of 30 bases within exon 23
• D) A deletion of 25 bases within exon 21
• E) An insertion of a corrected copy of exon 23 after the mutant exon 23

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Definitions:

Activity Cost Pools

Aggregations of all the overhead costs associated with specific activities, used in activity-based costing.

Customer Margin

The profit generated from a particular customer, calculated by subtracting the costs associated with serving that customer from the revenue they generate.

Serving Customers

The activities involved in providing products or services to customers effectively.

Activity Cost Pools

Accumulations of costs grouped by similar or related activities, used in activity-based costing to allocate costs more accurately.