A Scientist Edits a Mammalian Gene by Changing a Single

question 11

Multiple Choice

A scientist edits a mammalian gene by changing a single AT base pair to a GC base pair. Which of the following methods might she have used to make this change? (Select all that apply.)

• A) Site-directed mutagenesis
• B) Oligonucleotide-directed mutagenesis
• C) CRISPR-Cas9 genome editing followed by nonhomologous end joining (NHEJ)
• D) CRISPR-Cas9 genome editing followed by homologous recombination (HR) with a donor template
• E) Mutagenesis with radiation

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