A Mutation Occurs in the Trp Operon DNA of E

question 13

Multiple Choice

A mutation occurs in the trp operon DNA of E. coli and results in the change to the two UGG tryptophan codons in the 5' UTR of the RNA to UAG stop codons. What effect will this mutation be expected to have on the regulation of this mutant trp operon compared to a wild-type operon?

• A) In the presence of tryptophan, transcription of the structural genes will be reduced compared with a wild-type operon.
• B) In the absence of tryptophan, transcription of the structural genes will be reduced compared with a wild-type operon.
• C) In the presence of tryptophan, the repressor will bind to the operator/promoter region with the mutant operon more strongly than with a wild-type operon.
• D) In the absence of tryptophan, RNA polymerase will not bind to the operator/promoter region with the mutant operon.
• E) In the presence of tryptophan, transcription of the structural genes will be enhanced compared with a wild-type operon.

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