Explain the Effect on DNA Replication of Mutations That Destroy

question 9

Essay

Explain the effect on DNA replication of mutations that destroy each of the following activities in DNA polymerase. Also, for each kind of mutation, how might you detect the effect in an in vitro replication reaction?
a. 5'to 3' polymerase
b. 5'to 3' exonuclease
c. 3' to 5' exonuclease

---

Definitions:

Mississippians

People native to Mississippi, a state in the United States, or the ancient Native American culture known for constructing large earthen mounds in the Mississippi Valley region.

Pueblos

Indigenous communities in the Southwestern United States known for their unique adobe dwellings and cultural traditions.

Sixteenth Century

The period from 1501 to 1600 in the Common Era, marked by significant events like the Protestant Reformation and the voyages of discovery that led to the colonization of the Americas.

Spanish Colonization

Spanish Colonization refers to the period during which Spain expanded its territories in the Americas, the Caribbean, and the Pacific, imposing its culture, religion, and governance structures on indigenous populations.