The Radioactive Labeling Experiment Similar to Meselson and Stahl's Experiment

question 24

Multiple Choice

The radioactive labeling experiment similar to Meselson and Stahl's experiment was performed to determine what happens to histone proteins in eukaryotic DNA replication. Preexisting and newly synthesized histone proteins were labeled with radioactive isotopes of different atomic mass. Select the statement(s) that are consistent with the diagram shown. (Select all that apply.)

• A) The newly synthesized histone and preexisting histones exist separately and associate with a different pool of DNA.
• B) The newly synthesized histone and preexisting histones mix and form smeared bands, representing heterogeneous mixture.
• C) The newly synthesized histone only associates with newly synthesized DNA while the preexisting histone associates with the old DNA.
• D) The newly synthesized histone and preexisting histones tend to mix together and reassociate with DNA after each round of the replication.
• E) The preexisting histones tend to associate with newly synthesized DNA while the newly synthesized histone associates exclusively with the old DNA.

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