People with the HLA Haplotype A1, B8, DR3 Have an Increased

question 16

Multiple Choice

People with the HLA haplotype A1, B8, DR3 have an increased nonresponse rate to which vaccine?

• A)Polio
• B)Hepatitis B virus (HBV)
• C)Measles/mumps/rubella (MMR)
• D)Influenza virus
• E)Diptheria/pertussis/tetanus (DPT)

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Definitions:

Epistatic Effects

Interactions between different gene loci where the effect of one gene is modified by the presence or absence of one or more 'modifier genes'.

Quantitative Trait

A measurable phenotype that depends on the cumulative actions of many genes and possibly environmental factors.

Fitness Function

A concept used in genetics and evolutionary biology to measure an organism's ability to survive and reproduce.

Directional

Pertaining to or indicating the direction in which something is moving or facing; also refers to evolutionary changes in a population that favor a specific set of traits.