Which Observation Suggested to Sutherland the Involvement of a Second

question 60

Multiple Choice

Which observation suggested to Sutherland the involvement of a second messenger in epinephrine's effect on liver cells?

• A) Receptor studies indicated that epinephrine was a ligand.
• B) Glycogen breakdown was observed only when epinephrine was administered to intact cells.
• C) Glycogen breakdown was observed when epinephrine and glycogen phosphorylase were combined in a cell-free system.
• D) Epinephrine was known to have different effects on many types of cells.

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