Unequal Crossing Over During Prophase I Can Result in One

question 19

Multiple Choice

Unequal crossing over during prophase I can result in one sister chromosome with a deletion and another with a duplication. A mutated form of hemoglobin, so-called hemoglobin Lepore, exists in the human population. Hemoglobin Lepore has a deleted series of amino acids. If this mutated form was caused by unequal crossing over, what would be an expected consequence?

• A) There should also be persons whose hemoglobin contains two copies of the series of amino acids that is deleted in hemoglobin Lepore.
• B) Each of the genes in the hemoglobin gene family must show the same deletion.
• C) The deleted gene must have undergone exon shuffling.
• D) The deleted region must be located in a different area of the individual's genome.