Which of the Following Is True About Spongiform Encephalopathies

question 24

Multiple Choice

Which of the following is true about spongiform encephalopathies?

• A) Spongiform encephalopathies occur in a wide variety of mammals, but the infectious prions are species specific and do not cause disease in other species.
• B) Spontaneous cases of Creuztfeldt- Jakob disease may be caused by mutations during cell division in neuronal stem cells.
• C) The disease is tied to a normal cellular prion protein (PrPC) that is found mostly on the surface of neurons.
• D) When the normal prion protein encounters an abnormally shaped version of itself, PrPSC, the normal prion's shape is changed and it becomes an infectious PrPSC.
• E) Abnormal prions clump together and kill the affected neurons, which accounts for the spongelike appearance of brain tissue found in TSE autopsies.

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