How Do Polypeptide Drugs Work

question 14

Multiple Choice

How do polypeptide drugs work?

• A) They target the 50S subunit of prokaryotic ribosomes to block protein synthesis.
• B) They work by inhibiting transpeptidase enzymes that are central to building peptidoglycan by forming the protein crosslinks that bind peptidoglycan's carbohydrate chains together in a chain link fence- like structure.
• C) They interact with lipopolysaccharide and destabilize the outer membrane of the Gram- negative cell wall where they can then further destabilize the plasma membrane to cause cytoplasmic leakage and cell lysis.
• D) They target the DNA replication enzymes DNA gyrase and topoisomerases.
• E) They act as competitive inhibitors of folic acid production.

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