The Force-Frequency Relation in the Heart (The Relation Between Frequency

question 8

Multiple Choice

The force-frequency relation in the heart (the relation between frequency of stimulation and strength of the heart) is caused principally by

• A) Stretch of the cardiac muscle with Increasing frequency of stimulation
• B) Increased in the sensit ivity of the myofilaments to Ca₂+
• C) Phosphorylation of TnC
• D) Increased [Ca₂+] in the mitochondria
• E) Increased [Ca₂+] transients due to loading of the SR

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