Discuss the Cellular Factors That Might Make a Drug More

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The Answer is When a drug is labeled "narrow spectrum," meaning that it has activity against only a limited number of microbes, it is generally because of some form of natural resistance that many microbes develop against the drug. For example, many drugs work better against Gram- positive organisms than Gram- negative ones because of the outer membrane found in Gram- negative cell walls. This membrane does not allow these drugs to enter the cell as readily as they enter Gram- positive cells. Other cellular factors that can have an effect on the spectrum of action of a particular drug include the presence of R- plasmids in the cell that carries resistance genes; the presence of altered cell membrane or cell wall proteins that prevent the passage of some types of drugs; and alterations in a cell's metabolic pathways, which can make the cell more resistant to certain types of drugs.

Discuss the Cellular Factors That Might Make a Drug More

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