Brachydactyly Type D Is Human Autosomal Dominant Condition in Which

question 45

Multiple Choice

Brachydactyly type D is human autosomal dominant condition in which the thumbs are abnormally short and broad. In most cases, both thumbs are affected, but occasionally just one thumb is involved. The pedigree above shows a family in which brachydactlyly type D is segregating. Filled circles and squares represent females and males who have involvement of both thumbs. Half- filled in symbols represent family members with just one thumb affected? There is evidence of variable expressivity and incomplete penetrance in this family. Which individu most likely nonpenetrant for the trait?

• A) II- 4
• B) IV- 1
• C) IV- 5
• D) III- 5
• E) III- 11

---

Definitions:

Physical

Physical pertains to anything related to the body or the material world, as opposed to mental or virtual aspects.

Cumulative Voting

A method of voting used in elections for directors of a corporation, allowing shareholders to multiply the number of votes they have by the number of positions available and to allocate their votes among candidates as they see fit.

Minority Shareholders

Individuals or entities that own less than 50% of a company's shares and therefore have limited control over company decisions.

Shareholder's Derivative Suit

A legal action brought by a shareholder on behalf of a corporation to enforce the corporation's rights when the corporation's management fails to do so.