You Want to Calculate the Frequency of the Allele Causing

question 44

Multiple Choice

You want to calculate the frequency of the allele causing sickle cell disease in your patients, and you know the genotypes of every individual. Assuming the population is not in Hardy- Weinberg equilibrium due to population substructure, which method can be used to calculate allele frequency?

• A) genotype proportion method
• B) binomial expansion
• C) chi- square test
• D) allele- counting method
• E) square root method

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Definitions:

Variance

A measurement of the spread between numbers in a data set, indicating how much the numbers differ from the mean of the set.

Standard Deviation

A metric for assessing how much the data points differ or spread out in a collection of values.

Observations

Individual data points or recorded values from an experiment or study.

Geometric Mean

A type of mean or average, which indicates the central tendency of a set of numbers by using the product of their values (as opposed to the arithmetic mean which uses their sum).