Although No Specific Gene Alteration Has Yet Been Demonstrated as a Cause

question 52

Multiple Choice

Although no specific gene alteration has yet been demonstrated as a cause for schizophrenia (SZ) , it is known to have a strong genetic component. A recent study has found a strong association between SZ and a locus at chromosome 10q22- 23 in Ashkenazi Jewish and Taiwanese Han populations. Which of the following is probable?

• A) The neuregulin- 3 gene at this locus is mutated in all or most SZ cases.
• B) Other populations will have the same association with 10q22- 23.
• C) SZ exhibits significant genetic heterogeneity in different populations.
• D) People with SZ being characterized differently in various medical communities results in this association between the Jewish and Han populations.
• E) The region on 10q must include several genes associated with SZ.

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