A Pair- Rule Gene in Drosophila Called Runt Controls Nervous

question 29

Multiple Choice

A pair- rule gene in Drosophila called runt controls nervous system formation. In the mouse, runt controls blood cell formation and genital structures. In humans, the analog of runt, when mutated, causes children to lack collar bones, and the opening at the top of the skull fails to close. What kind of experiment could tell you whether these genes are conserved in function?

• A) sequencing the proteins encoded for by each of the species' runt genes
• B) an in vivo experiment that replaces the coding sequence of Drosophila runt gene with the coding sequence from the homologous mouse runt gene to see if the mouse gene allows the nervous system to develop.
• C) use of immunological methods to identify the target cells of the species' runt transcription factors
• D) an in vitro experiment that identifies the DNA binding sites of the Drosophila runt gene.
• E) sequencing of the runt genes from each of the three species

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Definitions:

Rash Emotionalism

Hasty, impulsive reactions or decisions driven by intense emotions rather than rational thought.

Unfreezing

The initial stage in the change process, involving reducing forces maintaining the organization's current state and increasing forces for change, making it ready for a new way.

Organizational Development (OD)

A planned, organization-wide effort to increase an organization's effectiveness and viability.

Tempered Radicals

Individuals within an organization who seek to drive change incrementally, balancing adherence to existing norms with advocating for reform.