Myoclonal Epilepsy and Ragged Red Fiber Disease (MERRF) Is a Human

question 12

Multiple Choice

Myoclonal epilepsy and ragged red fiber disease (MERRF) is a human condition named for the ragged red fibers of skeletal muscle cells and myoclonic epilepsy in affected individuals. People with this disorder have a mutation in a mitochondrial gene for a tRNA, specifically that for lysine. Affected individuals are heteroplastic. Why?

• A) Mutations of this gene are dominant.
• B) Mutations of this gene affect individuals before birth.
• C) Interference with translation is not fully rescued by importing lysine from the cytoplasm.
• D) Lysine is required in translation of every one of the mitochondrial genes.
• E) Homoplastic organelles would be inviable due to failures in translation.

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