In a Disease Associated with a Nucleotide Repeat, Anticipation Is

question 33

Multiple Choice

In a disease associated with a nucleotide repeat, anticipation is often noticed in subsequent generations, usually associated with a more severe phenotype. Which of the following is a more likely cause of anticipation?

• A) Highly repeated sequences are expressed more often.
• B) Children of affected parents receive more attention from physicians than other children.
• C) Alleles with a large number of repeats are unstable and change size from generation to generation.
• D) The sequences have greater stability in later generations.
• E) Family members are exposed to the same mutagens.

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Definitions:

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