A Client Has Been Started on Diltiazem (Cardizem), a Susbstrate

question 10

Multiple Choice

A client has been started on diltiazem (Cardizem) , a susbstrate of the cytochrome CYP3A4 isoenzyme system.Since the client also takes Phenobarbital for seizures, which is an inducer of the CYP3A4 isoenzyme system, the nurse recognizes that diltiazem:

• A)Will not be able to cross the blood brain barrier (BBB).
• B)Might be inactivated at a faster rate than normal.
• C)Might be excreted at a slower rate.
• D)Will be metabolized by the kidneys.

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Definitions:

Poisson Approximation

A methodology in statistics used to approximate the probability of a given number of events happening in a fixed interval of time or space.

Probability

The measure of likelihood that an event will occur, expressed as a number between 0 and 1.

Random Variable

A variable whose values depend on outcomes of a random phenomenon. It can be discrete or continuous.

Standard Deviation

A metric that quantifies the spread or variation of a dataset in comparison to its average value.