The Synonymous Substitution Rates Across a Given Genome Rarely Differ

question 9

Multiple Choice

The synonymous substitution rates across a given genome rarely differ by more than a factor of two, a difference that cannot account for the roughly 1,000-fold difference in nonsynonymous substitution rates observed between some genes. This observation strongly suggests

• A) that nonsynonymous substitutions are more common than synonymous substitutions.
• B) that natural selection has been acting on such genes.
• C) that genetic drift is a stronger evolutionary force than previously believed.
• D) that mutations rates are far more variable than previously believed.
• E) that synonymous substitution rates are underestimated.

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