Explain How the 3' Untranslated AU-Rich Sequence Element (ARE) Can

question 22

Essay

Explain how the 3' untranslated AU-rich sequence element (ARE) can control poly(A) tail length (and thus mRNA translatability) in opposite ways.

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Definitions:

Direct Labor-Hours

The total hours worked by employees directly involved in the manufacturing process or providing a service, used as a basis for allocating labor costs.

Fixed Manufacturing Overhead

Costs related to the production process that do not vary with the volume of production, such as rent, depreciation, and salaries of permanent staff.

Variable Overhead Rate

The rate at which variable overhead costs are allocated to production, based on a predetermined base such as direct labor hours or machine hours.

Direct Labor-Hours

The total hours worked by employees directly involved in the production process.