A Genetic Variation in How the Metabolite of the Cancer

question 6

Multiple Choice

A genetic variation in how the metabolite of the cancer drug irinotecan SN-38 is inactivated by the body may lead to:

• A)Decreased effectiveness of irinotecan in the treatment of cancer
• B)Increased adverse drug reactions, such as neutropenia
• C)Delayed metabolism of the prodrug irinotecan into the active metabolite SN-38
• D)Increased concerns for irinotecan being carcinogenic

---

Definitions:

Vision

The ability to see; the sense mediated by the eyes that allows for the perception of light, color, and depth.

Vitreous Body

The transparent gel-like substance filling the eye between the lens and the retina, providing it with its spherical shape.

Aqueous Humor

A clear, watery fluid found between the lens and the cornea of the eye, providing nutrition and maintaining intraocular pressure.

Eyeball

The sphere-shaped organ of vision contained within the orbit of the skull.