The Reaction Below Is a Direct Enolate Alkylation

question 27

Multiple Choice

The reaction below is a direct enolate alkylation.It has been found that this reaction only works well with unhindered methyl and 1° alkyl halides.Pick the statement that best explains this observation.

• A)The nucleophilic enolate requires a reaction center that has a positive charge.
• B)Hindered alkyl halides do not undergo S_N1 reactions.
• C)Hindered alkyl halides do not undergo S_N2 reactions.
• D)Methyl and 1° alkyl halides can form carbocations that can readily react with the nucleophilic enolate.

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Definitions:

One-Sample T-Test

A statistical test used to determine whether the mean of a sample differs significantly from a known or hypothesized population mean under the assumption of a normally distributed single sample.

Parametric Counterpart

A statistical method or test that assumes the underlying data follows a particular distribution, often used in contrast to nonparametric methods.

Randomized Block

A design for experiments where subjects are divided into blocks and then randomly assigned to treatments.

Spearman's Rank-Correlation

A nonparametric measure of rank correlation that assesses how well the relationship between two variables can be described using a monotonic function.