Sertraline (Shown Below) Is the Active Ingredient in the Antidepressant

question 19

Multiple Choice

Sertraline (shown below) is the active ingredient in the antidepressant Zoloft.

Pure sertraline has a specific rotation [α] of +37.9° in methanol solution. What would the observed rotation α be for a mixture of 5.75g of pure sertraline in 30.0 ml of methanol if the solution is placed in a 10.0 cm polarimeter cell?

• A) 72.6°
• B) 19.8°
• C) 7.26°
• D) 198°
• E) 0.726°

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