Which of These Factors Is Least Important in Determining the Regiochemistry

question 39

Multiple Choice

Which of these factors is least important in determining the regiochemistry of hydration of carbonyl compounds?

• A) the greater strength of the C-O versus the O-O bond.
• B) the pH under which the reaction takes place
• C) the greater ability of oxygen to accommodate a negative charge in the intermediate
• D) the greater orbital overlap at carbon for the π* orbital of the carbonyl
• E) All these factors are important in determining the regiochemistry of the addition.

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