The Antibiotic Rifamycin Is Selectively Toxic in Blocking Protein Synthesis

question 45

Multiple Choice

The antibiotic rifamycin is selectively toxic in blocking protein synthesis in Mycobacterium tuberculosis because _______.

• A) the antibiotic binds to the mRNA once synthesized, preventing it from participating in the initiation complex with the ribosome
• B) bacterial ribosomes are 70s whereas host ribosome are 80s, thus the antibiotic binds to the M. tuberculosis ribosome but does not bind to the eukaryotic machinery
• C) it binds preferentially to bacterial RNA polymerase rather than the eukaryotic protein, effectively halting transcription in the pathogen but not the host
• D) the drug binds to the initiator tRNA, preventing the formation of the protein synthesis initiation complex in the bacterial cell

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