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The first framework of the four frameworks approach is
Endorphins
Natural painkillers produced by the body, often associated with feelings of euphoria.
Proinflammatory Cytokines
Molecules produced by the immune system that promote inflammation and are involved in the body's response to disease and injury.
Efferent Neurons
Motor neurons that convey impulses away from the brain.
Nociception
The process wherein sensory nerve cells are stimulated in response to harmful stimuli resulting in the perception of pain.
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