[Solved] Why does it appear that each origin can only be activated once per cell cycle? A)MCM proteins are displaced from the DNA after replication and cannot reassociate with a replication origin that has already fired. B)The ORC is denatured after replication and cannot return to the DNA. C)The DNA becomes naked until the next round of cell division. D)MCM proteins reassociate with DNA immediately and prevent further replication from that DNA. E)MCM proteins bind to other proteins in the cytoplasm; together they actively inhibit further replication. Wilcoxon Rank Sum Test: A non-parametric statistical test used to compare two independent samples to assess whether their populations have identical distribution. Sign Test: A non-parametric statistical test used to assess the difference between matched pairs of samples when the specific data measurement scale does not meet the requirements for parametric testing. Binomial Tables: Pre-calculated tables used to find the probability of observing a certain number of successes in a fixed number of binary experiments. Large-sample Z Statistic: A statistical measure used when the sample size is large, typically applied in hypothesis testing to determine if there is a significant difference between sample statistics and population parameters.