Why Does the Activation of a Protein Kinase That Acts

question 4

Multiple Choice

Why does the activation of a protein kinase that acts on initiation factor eIF2 block protein synthesis?

• A)Phosphorylated eIF2 denatures.
• B)Phosphorylated eIF2 cannot exchange its GDP for GTP, which is required for eIF2 to participate in another round of translation initiation.
• C)Phosphorylated eIF2 cannot exchange its GTP for GDP, which is required for eIF2 to participate in another round of translation initiation.
• D)Phosphorylated eIF2 is hyperactivated, blocking further translation.
• E)Dephosphorylated eIF2 cannot exchange its GDP for GTP, which is required for eIF2 to participate in another round of translation initiation.

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Definitions:

Null Hypothesis

A statement used in statistical testing that assumes no effect or no difference between groups, serving as the default assumption to test against.

Alternative Hypotheses

In statistics, alternative hypotheses suggest that there is a significant difference, effect, or relationship between two variables.

Square Footage

A measure of area used primarily in the United States, equivalent to the area of a square with sides one foot in length.

P-value

A statistical measure indicating the probability of observing the given or more extreme outcome assuming the null hypothesis is true.