Why Does Targeting Glucocerebrosidase to Lysosomes in Macrophages Serve as a Treatment

question 141

Multiple Choice

Why does targeting glucocerebrosidase to lysosomes in macrophages serve as a treatment for Gaucher's disease?

• A)Glucocerebrosidase is normally denatured in the lysosomes.
• B)Glucocerebrosidase is delivered to the precise sites in the cell where the deficiency is manifested, correcting the deficit.
• C)Glucocerebrosidase denatures the cytoplasm from its location in the lysosomes, correcting the deficit.
• D)Glucocerebrosidase binds to the outer lysosome surface and breaks down glycogen in the cytoplasm.
• E)Glucocerbrosidase is supposed to digest most of the enzymes in the lysosome.

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Definitions:

Hippocampus

An area in the brain linked to the creation, structuring, and retention of memories.

Prefrontal Lobes

Regions of the frontal lobes of the brain associated with complex cognitive behavior, personality, decision making, and moderating social behavior.

Working Memory

A cognitive system responsible for temporarily holding and processing information needed for complex cognitive tasks like learning, reasoning, and comprehension.

Cell Breakdown

The process in which cells degrade or disintegrate, often due to disease, injury, or the natural aging process.