You Are Investigating the Interactions of Integrin $\alpha$ And $\beta$ Subunits and Isolate the Extracellular Portion of an Integrin as Subunits

question 34

Multiple Choice

You are investigating the interactions of integrin $\alpha$ and $\beta$ subunits and isolate the extracellular portion of an integrin as a soluble $\alpha$ / $\beta$ heterodimer. The heterodimer lacks the associated transmembrane and cytoplasmic domains normally present as part of the molecule. You experimentally link the $\alpha$ and $\beta$ subunits at the bases of their legs so that the ligand-binding regions of the $\alpha$ and $\beta$ subunits approach one another and the legs are in the bent conformation. Which of the following statements is the best prediction of what will happen?

• A)The molecules will bind their ligand tightly.
• B)The molecules will be unable to bind a ligand.
• C)The molecules will be cleaved.
• D)The molecules will denature their ligand.
• E)The molecules will denature and degrade.

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