Garrod's Information About the Enzyme Alteration Resulting in Alkaptonuria Led

question 6

Multiple Choice

Garrod's information about the enzyme alteration resulting in alkaptonuria led to further elucidation of the same pathway in humans. Phenylketonuria (PKU) occurs when another enzyme in the pathway is altered or missing, resulting in a failure of phenylalanine (phe) to be metabolized to another amino acid: tyrosine. Tyrosine is an earlier substrate in the pathway altered in alkaptonuria. How might PKU affect the presence or absence of alkaptonuria?

• A) It would have no effect, because PKU occurs several steps away in the pathway.
• B) It would have no effect, because tyrosine is also available from the diet.
• C) Anyone with PKU must also have alkaptonuria.
• D) Anyone with PKU is born with a predisposition to later alkaptonuria.
• E) Anyone with PKU has mild symptoms of alkaptonuria.

---

Definitions:

Dizziness

A sensation of spinning or lightheadedness, which may result in a loss of balance.

Cardiopulmonary Resuscitation

An emergency procedure consisting of external chest compressions and artificial ventilation to manually preserve intact brain function until further measures to restore spontaneous blood circulation and breathing in a person who is in cardiac arrest.

Rescue Breaths

Part of lifesaving techniques, these are breaths given to someone not breathing normally, to provide oxygen until normal breathing resumes or advanced help arrives.

Compressions

Actions that apply pressure to a part of the body, often used in first aid to stop bleeding or in cardiopulmonary resuscitation.