Use the Following Information to Answer the Next Few Questions

question 43

Multiple Choice

Use the following information to answer the next few questions.
Poliovirus is a positive-sense RNA virus of the picornavirus group. At its 5' end, the RNA genome has a viral protein (VPg) instead of a 5' cap. This is followed by a nontranslated leader sequence, and then a single long protein coding region (~7,000 nucleotides) , followed by a poly-A tail. Observations were made that used radioactive amino acid analogues. Short period use of the radioactive amino acids result in labeling of only very long proteins, while longer periods of labeling result in several different short polypeptides.
-What part of the poliovirus would first interact with host cell ribosomes to mediate translation?

• A) the poly-A tail
• B) the leader sequence
• C) the VPg protein
• D) the AUG in the leader sequence
• E) the AUG at the start of the coding sequence

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