Use the Following Information to Answer the Next Few Questions

question 41

Multiple Choice

Use the following information to answer the next few questions.
CML (chronic myelogenous leukemia) results from a translocation between human chromosomes 9 and 22. The resulting chromosome 22 is significantly shorter than usual, and it is known as a Philadelphia (Ph') chromosome. The junction at the site of the translocation causes overexpression of a thymine kinase receptor. A new drug (Gleevec or imatinib) has been found to inhibit the disease if the patient is treated early.
-Why would Gleevec most probably cause remission of the disease?

• A) It reverses the chromosomal translocation.
• B) It eliminates the Ph' chromosome.
• C) It removes Ph'-containing progenitor cells.
• D) The drug inhibits the replication of the affected chromosome.
• E) The drug inhibits the specific thymine kinase receptor.

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Definitions:

Psychosexual Development

A Freudian concept describing how personality develops through stages characterized by a focus on erogenous zones.

Personality Growth

The process of developing and maturing one's personality, often involving increased self-awareness, emotional regulation, and improved social skills.

Erikson

Refers to Erik Erikson, a developmental psychologist and psychoanalyst known for his theory on the psychosocial development of human beings.

Anna Freud

A pioneering psychoanalyst, particularly in the field of child psychoanalysis, and the daughter of Sigmund Freud.