Unequal Crossing Over During Prophase I Can Result in One

question 9

Multiple Choice

Unequal crossing over during prophase I can result in one sister chromosome with a deletion and another with a duplication. A mutated form of hemoglobin, known as hemoglobin Lepore, is known in the human population. Hemoglobin Lepore has a deleted set of amino acids. If it was caused by unequal crossing over, what would be an expected consequence?

• A) If it is still maintained in the human population, hemoglobin Lepore must be selected for in evolution.
• B) There should also be persons born with, if not living long lives with, an anti-Lepore mutation or duplication.
• C) Each of the genes in the hemoglobin gene family must show the same deletion.
• D) The deleted gene must have undergone exon shuffling.
• E) The deleted region must be located in a different area of the individual's genome.

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