The Following Questions Refer to the Following Paragraph

question 11

Multiple Choice

The following questions refer to the following paragraph.
HIV's genome of RNA includes the code for reverse transcriptase (RT) , an enzyme that acts early in infection to synthesize a DNA genome off of an RNA template. The HIV genome also codes for protease (PR) , an enzyme that acts later in infection by cutting long viral polyproteins into smaller, functional proteins. Both RT and PR represent potential targets for antiretroviral drugs. Drugs called nucleoside analogs (NA) act against RT, whereas drugs called protease inhibitors (PI) act against PR.
-Within the body of an HIV-infected individual who is being treated with a single NA, and whose HIV particles are currently vulnerable to this NA, which of these situations can increase the virus' relative fitness?
1) mutations resulting in RTs with decreased rates of nucleotide mismatch
2) mutations resulting in RTs with increased rates of nucleotide mismatch
3) mutations resulting in RTs that have proofreading capability

• A) 1 only
• B) 2 only
• C) 3 only
• D) 1 and 3
• E) 2 and 3

---

Definitions:

Equestrian Statues

Sculptures representing figures, typically historical or heroic, mounted on horseback, symbolizing power and status.

Marcus Aurelius

Roman Emperor from 161 to 180 AD and a Stoic philosopher, known for his work 'Meditations' and his role in the Roman Empire's history.

Rome's Glory

A reference to the period of prosperity and expansive power of the Roman Empire, marked by significant achievements in architecture, engineering, law, and the arts.

Prestige Adornment

Objects or accessories worn that signify wealth, status, or authority, often made from precious materials and detailed craftsmanship.