Pyruvate Kinase Deficiency Is a Genetic Condition Resulting from a Mutation

question 66

Multiple Choice

Pyruvate kinase deficiency is a genetic condition resulting from a mutation in the gene coding for one of the enzymes of glycolysis, pyruvate kinase. It mostly affects red blood cells, and leads to irregular morphology of red blood cells and hemolytic anemia. Yet, pyruvate kinase is present in all cells where it catalyzes one step of glycolysis. Which of the following best explain why red blood cells are MOST affected in this disorder?

• A) Defect of glycolysis enzyme leads to lower levels of ATP in red blood cells.
• B) Red blood cells exclusively rely on glycolysis as their ATP source.
• C) Red blood cells cannot produce ATP from beta oxidation of fatty acids.
• D) All of the choices are correct.

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Definitions:

Competition

A biological interaction where organisms vie for the same resources, such as food, space, or mates, in an ecosystem, influencing the structure and diversity of communities.

Ecological Niche

The role and position a species has in its environment, including all of its interactions with the biotic and abiotic factors.

Trophic Level

The position an organism occupies in a food chain, defined by the number of steps it is from the primary source of energy.

Community Structure

The composition and arrangement of the biotic component in a particular area, often considering the diversity and abundance of species.