Azidothymidine (AZT) Is a Nucleoside Analog Reverse Transcriptase Inhibitor, Which

question 8

Multiple Choice

Azidothymidine (AZT) is a nucleoside analog reverse transcriptase inhibitor, which is an antiretroviral drug. It was the first drug approved for the treatment of HIV. AZT was the major breakthrough in AIDS therapy in the 1990's.

What is the function of AZT, based on its structure?

• A) The azido-group (-N₃) facilitates irreversible binding to reverse transcriptase.
• B) The azido-group (-N₃) facilitates irreversible binding to a neighboring nucleotide.
• C) AZT cannot be incorporated into a DNA-strand during reverse transcription of the genetic code from RNA to DNA after retroviral infection.
• D) All of the above

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Definitions:

Morphology

The study of the form and structure of organisms and their specific structural features.

Coagulation

The process by which blood changes from a liquid to a gel, forming a clot, which is crucial in preventing excessive bleeding from injuries.

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A blood test that measures the average level of glucose attached to hemoglobin over the past 2 to 3 months, indicating the long-term control of blood sugar levels.

Blood Urea Nitrogen

A measurement of the urea nitrogen levels in blood, often used to assess kidney function and health.