Urokinase-Type Plasminogen Activator (UPa) Is a Serine Endopeptidase

question 3

Multiple Choice

Urokinase-type Plasminogen Activator (uPa) is a serine endopeptidase. The active site of this peptidase binds the peptide-motif Ser-Gly-Arg-Ser-Ala and cleaves the protein/peptide between arginine and serine. What is the sequence of the products of the oligopeptide
Ala-Gly-Ser-Gly-Arg-Ser-Ala-Lys-Gly-Ala-Ser-Asp
After cleavage by uPa?

• A) Ala-Gly and Ser-Gly-Arg-Ser-Ala-Lys-Gly-Ala-Ser-Asp
• B) Ala-Gly-Ser-Gly-Arg and Ser-Ala-Lys-Gly-Ala-Ser-Asp
• C) Ala-Gly-Ser-Gly-Arg-Ser-Ala-Lys-Gly-Ala-Ser and Asp
• D) Ala-Gly-Ser-Gly-Arg-Ser and Ala-Lys-Gly-Ala-Ser-Asp

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Definitions:

Pituitary

A small gland at the base of the brain, important for controlling growth, metabolism, and the function of other glands in the endocrine system.

Hypothalamus

A region of the brain below the thalamus that coordinates the autonomic nervous system and the activity of the pituitary, controlling body temperature, hunger, and other essential functions.

Oxytocin

A hormone that plays roles in social bonding, sexual reproduction, childbirth, and the period after childbirth.

Nursing

The profession or practice of providing care for the sick and infirm.